Results of bone marrow examination in patients presenting with pancytopenia and high mean corpuscular volume

Abstract

Background: Most of the causes of pancytopenia are associated with normocytic normochromic red cell indices but certain causes are associated with high mean corpuscular volume. This study aimed to determine the frequency of causes of pancytopenia with high mean corpuscular volume.

Methods: This crosssectional study was conducted at Pathology Department, King Edward Medical University Lahore and included all the cases from affiliated hospitals from 30th January 2011 to 30th June 2011. The calculated sample size was 150 cases. Patients having pancytopenia and macrocytosis were included in the study. The data was analyzed on SPSS 13 to determine the frequencies and percentages.

Results: Results of bone marrow biopsy showed aplastic anemia in (50.67%), megaloblastic anemia (36.6%), leukemia (7.3%) and myelodysplastic syndrome in (5.3%) of these patients.

Conclusion: Aplastic and megaloblastic anemia are the commonest causes of pancytopenia with high mean corpuscular volume.