NAUSEA AND VOMITING IN FIRST-TRIMESTER PREGNANCY: IS HELICOBACTER PYLORUS A RISK FACTOR?
Abstract
Background: Nausea and vomiting in pregnancy could lead to adverse fetal and maternal outcomes. The aim of this study was to investigate the association between Helicobacter pylori infection and both the frequency and severity of nausea and vomiting in pregnant women before 20 weeks of gestation.
Materials & Methods: This descriptive cross-sectional study was conducted on all one hundred pregnant women with nausea and vomiting during the study period, from May 1, 2022, to April 30, 2023, in the Obstetrics and Gynecology Department of the Maternity Teaching Hospital in Dohuk, Kurdistan Region of Iraq. The H.pylori infection was assessed through IgG testing by ELISA.
Results: The H. Pylori test was positive in 56% of pregnant women with Nausea and Vomiting (N&V). There was a highly significant association between cesarean section and pregnant women with preterm birth. There was a significant association between increased age and gestational age of pregnant women with N&V and positive H. Pylori test (p<0.05). There was a highly significant association between normal General Urine Examination (GUE) of pregnant women with N&V and positive H. Pylori test (p<0.001).
Conclusions: The prevalence of H. pylori infection among pregnant women with nausea and vomiting is high.
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El Tamamy EAr, Abdel Fattah AT, Hemdan MHAI. The relation between Helicobacter pylori seropositivity and hyperemesis gravidarum in pregnant women during first trimester. Egypt J Hosp Med. 2019;77(2):4894-8. https://doi.org/10.21608/ejhm.2019.47454.
Cummings MJ, Baldwin MR, Abrams D, Jacobson SD, Meyer BJ, Balough EM, et al. Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study. Lancet. 2020;395(10239):1763-70. https://doi.org/10.1016/S0140-6736(20)31189-2.
Liu C, Zhao G, Qiao D, Wang L, He Y, Zhao M, et al. Emerging progress in nausea and vomiting of pregnancy and hyperemesis gravidarum: challenges and opportunities. Front Med. 2021;8:809270. https://doi.org/10.3389/fmed.2021.809270.
Feng Y, Huang Q, Luo M, Wei J, Gao T, Chu D, et al. The association between Helicobacter pylori and gastrointestinal disorders during pregnancy: a multicenter retrospective study. Helicobacter. 2024;29(1):e13032. https://doi.org/10.1111/hel.13032.
Tuzcuoğlu SHAİ, Soysa ME. The prevalence of Helicobacter pylori in the stools of pregnant women with hyperemesis gravidarum. Anatol J Family Med. 2023;6(2):69-74. https://doi.org/10.5505/anatoljfm.2023.27136.
Hussein KS. Hyperemesis gravidarum in first-trimester pregnant Saudi women: is Helicobacter pylori a risk factor? Front Physiol. 2020;11:575. https://doi.org/10.3389/fphys.2020.00575.
Ghazanfar H, Javed N, Reina R, Thartori O, Ghazanfar A, Patel H. Advances in diagnostic modalities for Helicobacter pylori infection. Life. 2024;14(9):1170. https://doi.org/10.3390/life14091170.
Ioannidou P, Papanikolaou D, Mikos T, Mastorakos G, Goulis DG. Predictive factors of hyperemesis gravidarum: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2019;238:178-87. https://doi.org/10.1016/j.ejogrb.2019.04.043.
Li J, Fan M, Ma F, Zhang S, Li Q. The effects of Helicobacter pylori infection on pregnancy-related diseases and fetal development in diabetes in pregnancy. Ann Transl Med. 2021;9(8):686. https://doi.org/10.21037/atm-21-1209.
Aydın M, Tolunay HE, Varlı EN, Boza B, Şahin Ö, Özer S, et al. Helicobacter pylori infection in amniotic fluid may cause hyperemesis gravidarum. Yale J Biol Med. 2020;93(4):487-93. [PMC7513450].
Shahab LS, HA. Relation of Helicobacter pylori and hyperemesis gravidarum in a sample of pregnant women in Maternity Teaching Hospital of Erbil city. AMJ. 2023;8(1):15-21. https://doi.org/10.56056/amj.2023.193.
Suhartat S. The relation of age and parity with the incidence of hyperemesis gravidarum in pregnant women in Dr. H. Moch Ansari Saleh Banjarmasin Hospital. Proceedings of the First National Seminar Universitas Sari Mulia, NS-UNISM 2019, 23rd November 2019, Banjarmasin, South Kalimantan, Indonesia; 2020. https://doi.org/10.4108/eai.23-11-2019.2298361.
Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, et al. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat Rev Dis Primers. 2019;5(1):62. https://doi.org/10.1038/s41572-019-0110-3.
Poeran-Bahadoer S, Jaddoe VWV, Gishti O, Grooten IJ, Franco OH, Hofman A, et al. Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study. J Dev Orig Health Dis. 2019;11(2):118-26. https://doi.org/10.1017/S2040174419000114.
Regodón Wallin A, Tielsch JM, Khatry SK, Mullany LC, Englund JA, Chu H, et al. Nausea, vomiting and poor appetite during pregnancy and adverse birth outcomes in rural Nepal: an observational cohort study. BMC Pregnancy Childbirth. 2020;20(1):545. https://doi.org/10.1186/s12884-020-03141-1.
Zhu S, Zhao A, Lan H, Li P, Mao S, Szeto IM-Y, et al. Nausea and vomiting during early pregnancy among Chinese women and its association with nutritional intakes. Nutrients. 2023;15(4):933. https://doi.org/10.3390/nu15040933.
Nejadi JR, Shamseh M, Ronasi N, Birjandi M, Karimi A. Comparison of the effects of dexamethasone and ondansetron on the reduction of postoperative nausea and vomiting following cesarean section under spinal anesthesia. Curr Rev Clin Exp Pharmacol. 2021;16(1):117-22. https://doi.org/10.2174/1574884715666200302122800.
Jin B, Han Y, Jiang Y, Zhang J, Shen W, Zhang Y. Acupuncture for nausea and vomiting during pregnancy: a systematic review and meta-analysis. Complement Ther Med. 2024;85:103079. https://doi.org/10.1016/j.ctim.2024.103079.
Rasin BH, AR. Association between hyperemesis gravidarum in Iraqi women with Helicobacter pylori infection. Egypt J Hosp Med. 2022:5653-9. https://doi.org/10.21608/ejhm.2022.266022.
O E. The association between Helicobacter pylori infection and hyperemesis gravidarum. Al-Azhar Int Med J. 2020;1(4):32-6. https://doi.org/10.21608/aimj.2020.22069.1054.
Adane KD, Zerga AA, Gebeyehu FB, Ayele FY. Proportion of hyperemesis gravidarum and associated factors among pregnant women admitted into the obstetrics ward at Akesta General Hospital, North East Ethiopia. PLoS One. 2023;18(2):e0281433. https://doi.org/10.1371/journal.pone.0281433.
Beyene GA, Ayele ND, Kasahun AW. Prevalence and determinants of hyperemesis gravidarum among pregnant women in Ethiopia: a systematic review and meta-analysis. PLoS One. 2024;19(12):e0314783. https://doi.org/10.1371/journal.pone.0314783.
Wang SJ, Hsieh CJ, Su YH, Lin LL, Chen WC, Chen HH, et al. Assessment of adverse pregnancy outcomes associated with Helicobacter pylori infection. Sci Rep. 2024;14(1):32023. https://doi.org/10.1038/s41598-024-83694-9.
Masaadeh AH, Mathias PC, Ford BA, Bosch DE. Helicobacter pylori exposure in nausea and vomiting of pregnancy increases risk of preterm delivery. Infect Dis Obstet Gynecol. 2023;2023:6612268. https://doi.org/10.1155/2023/6612268.
DOI: https://doi.org/10.46903/gjms/23.1.1807
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