In-Hospital Outcome of patients having Acute Myocardial Infarction with and without Streptokinase

Abstract

Background: Acute myocardial infarction is the leading cause of death. Streptokinase is the most commonly used thrombolytic agent. This study was conducted to compare in-hospital outcome of patients with acute myocardial infarction receiving streptokinase with those not receiving it.

Material & Methods: This descriptive observational study was conducted at Coronary Care Unit, DHQ Teaching Hospital D.I.Khan from 1st August 2005 to 31st July 2007. 340 patients having acute MI were included in the study. Two groups were formed: sk group receiving streptokinase and non-sk group not receiving. In-hospital mortality was the primary end point while mechanical and electrical complications were the secondary end points.

Results: Among 340 patients, 255(75%) were males and 85(25%) females. Out of those 218 received streptokinase, while 122 did not. Mean age of sk group was 53.15±10.30 years and non-sk group 60.5±16 years. Mean time of arrival to the hospital after symptom onset was 10.41±9.97 hours. SK group patients reached in 5.9±4.76 hours while non-sk group in 19.4±10.5 hours. In-hospital mortality in sk and non-sk group was 19(8.7%) and 25(20.5%) respectively, p=0.002. Complication rate was significantly higher in the non-sk group, 54.09% vs 34.86%, p=0.04.

Conclusion: Patients of acute myocardial infarction receiving streptokinase have significantly lesser inhospital mortality and complications as compared to patients not receiving it.