TOXIC EFFECTS OF AFLATOXIN B1 ON SOME SERUM HORMONES LEVELS IN TYPE 2 DIABETES FEMALE PATIENTS

Zainab Ali Mohsin; Sami Abdul-Redha Al-Jumaily

doi:10.46903/gjms/23.4.Suppl.2055

TOXIC EFFECTS OF AFLATOXIN B1 ON SOME SERUM HORMONES LEVELS IN TYPE 2 DIABETES FEMALE PATIENTS

Zainab Ali Mohsin, Sami Abdul-Redha Al-Jumaily

Abstract

Background: Aflatoxin B1 (AFB1) is a potent mycotoxin known to exert toxic effects on various biological systems, including the endocrine system. Women with diabetes mellitus type 2 (DMT2) may be particularly vulnerable to hormonal disturbances, especially when exposed to environmental toxins like AFB1. The aim of this present study was to investigate an examination of AFB1 in patients’ blood with DMT2 and the correlation between some specific Hormone levels of patients.

Materials & Methods: A case-control study was worked in Diabetes and Endocrinology Center at Imam Al-Hussein Hospital, from September to December 2024. A total of 100 women (50 DMT2 patients and 50 healthy controls) aged 35–65 years were enrolled. Blood samples were collected to measure serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, Estradiol (E2), and testosterone using the Abbott Architect i2000SR system. AFB1 levels were detected using Thin Layer Chromatography (TLC) and quantified by HPLC. In order to perform the statistical analysis, version 26 of SPSS was utilized.

Results: AFB1 demonstrated a positive correlation with DMT2 (r = 0.319), and E2 levels showed a significant decrease, while testosterone and prolactin levels exhibited a notable increase in the toxin-exposed group, additionally, both LH and FSH levels were significantly reduced in patients exposed to the toxin. Assessment of receiver Characteristics curve (ROC) analysis showed that AFB1 Toxin is considered reasonably excellent for DMT2 patients with a sensitivity 90.000% and a specificity of 97.500%.

Conclusion: Exposure to AFB1 may contribute to hormonal dysregulation in women with DMT2, suggesting a potential link between environmental toxins and endocrine complications in diabetic patients.

Keywords

Aflatoxin B1; Diabetes Mellitus; Endocrine hormones; Estradiol; Prolactin; Testosterone; Type 2 diabetes mellitus.

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DOI: https://doi.org/10.46903/gjms/23.4.Suppl.2055