MELATONIN AS AN ADJUNCTIVE THERAPY WITH ETANERCEPT FOR IRAQI PSORIATIC PATIENTS

Ghadah Ali Al-Oudah; Ihab I.Alkhalifa; Shaimaa M. Mohammed; Ali Ameer Al-Ameedee

doi:10.46903/gjms/23.3.1921

MELATONIN AS AN ADJUNCTIVE THERAPY WITH ETANERCEPT FOR IRAQI PSORIATIC PATIENTS

Ghadah Ali Al-Oudah, Ihab I.Alkhalifa, Shaimaa M. Mohammed, Ali Ameer Al-Ameedee

Abstract

Background: Treatment with melatonin as anti-oxidant’s supplements may has a role in psoriasis with diminished anti-oxidant system function. This medical trial targets the efficiency of melatonin as an adjunctive management with etanercept in mitigating the severity of chronic plaque psoriasis.

Material & Methods: A double-blind prospective randomized clinical trial study conducted over a three-month period from 1st January 2022 to 30th March 2022 at Department of Dermatology at Merjan Teaching Hospital in Babylon City / Iraq to assess the efficiency of melatonin as adjuvant therapy with etanercept in the management of psoriasis. Sixty adult patients (18 female, 42 males; age range 17-60 years) with psoriasis were selected through convenience sampling & distributed randomly into (2) groups. The group (A, n=30) received etanercept and placebo, whilst Group (B, n=30) received etanercept plus melatonin, orally, once daily. Psoriasis Area and Severity Index scores as a severity measuring index and blood levels of malondialdehyde and superoxide dismutase were assessed at baseline and at the completion of the intervention.

Results: A significantly improvement in the PASI score and oxidative indicators (MDA and SOD) were observed following both biological therapy and adjunctive melatonin treatment; For group A representing a 69.14% improvement. While for group D, PASI score, MDA and SOD representing an 81.87% improvement.

Conclusion: The daily administration adjuvant therapy 5 mg melatonin supplementation with etanercept to patients with psoriasis for 3months had reduce the severity of disease in a short period time.

Keywords

Anti-Oxidant; Etanercept; Melatonin; Oxidative Stress; Psoriasis.

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DOI: https://doi.org/10.46903/gjms/23.3.1921