RELATIONSHIP BETWEEN THE HEPATITIS B VIRUS INFECTION AND THE TNF-α-308(G/A) PROMOTER GENE POLYMORPHISM IN IRAQI PATIENTS

Gailan Abdulrazaq Alsamarai

doi:10.46903/gjms/23.3.1908

RELATIONSHIP BETWEEN THE HEPATITIS B VIRUS INFECTION AND THE TNF-α-308(G/A) PROMOTER GENE POLYMORPHISM IN IRAQI PATIENTS

Gailan Abdulrazaq Alsamarai

Abstract

Background: Tumor necrosis factor (TNF-α) is a key host factor that regulates immune responses and inflammation during infections The objective of this study was to know the connotation between TNF-α-308(G/A) polymorphism and HBV infection in Iraqi patients. https://admission.hed.gkp.pk/page.php?college_id=205&page_id=2501

Materials & Methods: A total of 100 HBV-infected patients and 40 healthy controls were genotyped. Genotype frequencies and allele distributions were analyzed and compared between patients and controls.

Results: The G/G genotype was more prevalent among patients, while the A/A genotype was absent in HBV cases but present in controls. Patients with higher occurrence of the G allele (84%) than controls (42.5%), whereas controls had a higher occurrence of the A allele (57.5%). Statistical analysis revealed a significant difference in genotype and allele distributions, with a X2 value of 62.27 (p < 0.0001).

Conclusions: The TNF-α-308(G/A) polymorphism has been associated to an increased risk of HBV infection, with the G/G genotype increasing the risk of infection and the A allele providing potential resistance.

Keywords

TNF-α; polymorphism; hepatitis B virus; Iraqi population; genetic susceptibility.

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DOI: https://doi.org/10.46903/gjms/23.3.1908