THE EFFECT OF AGE ON ANTI-MÜLLERIAN HORMONE LEVEL IN OBESE VERSUS NON OBESE INFERTILE PATIENTS IN AL DIWANIYAH CITY

Shaymaa Majeed Hamzah Alshammari

doi:10.46903/gjms/23.1.1847

THE EFFECT OF AGE ON ANTI-MÜLLERIAN HORMONE LEVEL IN OBESE VERSUS NON OBESE INFERTILE PATIENTS IN AL DIWANIYAH CITY

Shaymaa Majeed Hamzah Alshammari

Abstract

Background: The fertility of women entirely depends upon their age. Fertility reaches peak levels in the early twenties and begins to diminish in the third and fourth decades of life, declining significantly beyond the age of 35. Aim of this study was to evaluate the Effect of Age on Anti-Müllerian Hormone levels in Obese.

Materials & Methods: This retrospective, single-centre study followed 400 patients who attended an Obstetrics and Gynecology clinic in AL Diwaniyah from 14/12/2022 to 29/08/2024. Age(≥35 years versus <35 years), Body mass index (BMI), and (AMH) test results were inclusion criteria that participants were required to meet.

Results: The infertile women’s mean age was 32.53 ±7.73 years. In this study, infertile women were categorized into two groups based on age (≥35 years versus <35 years); the mean age in these groups was 41.09 ±3.92 years versus 27.49 ±4.14 years, consecutively (p <0.001). A comparison of mean body mass index (BMI) revealed that women ≥35 years had a mean BMI that was significantly greater than that of women <35 years. The comparison of serum AMH mean according to age and BMI shows that the difference was significant (p <0.001); the highest mean level was reported in the <35-Non-obese group, followed by <35-Obese group, then by ≥35-Non-obese and ≥35 –Obese groups.

Conclusion: The correlation between age of all enrolled infertile women and serum AMH level was significant and negative.

Keywords

Age; Infertility; Obese; Hormone; Al diwaniyah.

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References

Sladden T, Philpott A, Braeken D, Castellanos-Usigli A, Yadav V, Christie E, et al. Sexual health and wellbeing through the life course: Ensuring sexual health, rights and pleasure for all. Int J Sex Health. 2021 Oct 2;33(4):565-71. https://doi.org/10.1080/19317611.2021.1991071

Das PK, Mukherjee J, Banerjee D. Female reproductive physiology. In: Textbook of veterinary physiology. Singapore: Springer Nature Singapore; 2023. p. 513-68. https://doi.org/10.1007/978-981-19-9410-4_22

Garvey WT. New horizons. A new paradigm for treating to target with second-generation obesity medications. J Clin Endocrinol Metab. 2022 Apr 1;107(4):e1339-47. https://doi.org/10.1210/clinem/dgab848

Penzias A, Azziz R, Bendikson K, Falcone T, Hansen K, Hill M, et al. Obesity and reproduction: a committee opinion. Fertil Steril. 2021 Nov 1;116(5):1266-85. https://doi.org/10.1016/j.fertnstert.2021.08.018

Hales CM. Prevalence of Obesity and Severe Obesity Among Adults: US Department of Health and Human Services, Centers for Disease Control and Prevention; 2020.

Marinelli S, Napoletano G, Straccamore M, Basile G. Female obesity and infertility: outcomes and regulatory guidance. Acta Biomed. 2022;93(4).

Masood B, Moorthy M. Causes of obesity: a review. Clin Med (Lond). 2023 Jul 1;23(4):284-91. https://doi.org/10.7861/clinmed.2023-0168

Kazemi M, Jarrett BY, Vanden Brink H, Lin AW, Hoeger KM, Spandorfer SD, et al. Obesity, insulin resistance, and hyperandrogenism mediate the link between poor diet quality and ovarian dysmorphology in reproductive-aged women. Nutrients. 2020;12(7):1953. https://doi.org/10.3390/nu12071953

Alfaris N, Alqahtani AM, Alamuddin N, Rigas G. Global impact of obesity. Gastroenterol Clin North Am. 2023 Jun 1;52(2):277-93. https://doi.org/10.1016/j.gtc.2023.03.002

Zheng L, Yang L, Guo Z, Yao N, Zhang S, Pu P. Obesity and its impact on female reproductive health: Unraveling the connections. Front Endocrinol (Lausanne). 2024 Jan 9;14:1326546. https://doi.org/10.3389/fendo.2023.1326546

Incedal Irgat S, Bakirhan H. The effect of obesity on human reproductive health and foetal life. Hum Fertil (Camb). 2022 Oct 20;25(5):860-71. https://doi.org/10.1080/14647273.2021.1928774

Xie F, You Y, Guan C, Gu Y, Yao F, Xu J. Association between physical activity and infertility: a comprehensive systematic review and meta-analysis. J Transl Med. 2022 May 23;20(1):237. https://doi.org/10.1186/s12967-022-03426-3

Gonzalez MB, Robker RL, Rose RD. Obesity and oocyte quality: significant implications for ART and emerging mechanistic insights. Biol Reprod. 2022 Feb;106(2):338-50. https://doi.org/10.1093/biolre/ioab228

Wang RQ, Deng ZM, Chen GT, Dai FF, Xia LB. Obesity and recurrent spontaneous abortion: the crucial role of weight management in pregnancy. Reprod Biol Endocrinol. 2025 Jan 22;23(1):10. https://doi.org/10.1186/s12958-024-01326-3

Oldfield AL, Kazemi M, Lujan ME. Impact of obesity on anti-müllerian hormone (AMH) levels in women of reproductive age. J Clin Med. 2021 Jul 20;10(14):3192. https://doi.org/10.3390/jcm10143192

Jaswa EG, Rios JS, Cedars MI, Santoro NF, Pavone MEG, Legro RS, et al. Increased body mass index is associated with a nondilutional reduction in antimüllerian hormone. J Clin Endocrinol Metab. 2020;105(10):3234-42. https://doi.org/10.1210/clinem/dgaa436

Gürsu T, Eraslan A, Angun B. Comparison of body mass index, anti-müllerian hormone and insulin resistance parameters among different phenotypes of polycystic ovary syndrome. Gynecol Obstet Clin Med. 2022 Dec 1;2(4):164-70. https://doi.org/10.1016/j.gocm.2022.10.002

Luu TH, Kuhn K, Bradford AP, Wempe MF, Wittenburg L, Johnson RL, et al. Effects of pulsatile intravenous follicle-stimulating hormone treatment on ovarian function in women with obesity. Fertil Steril. 2023 Oct 1;120(4):890-8. https://doi.org/10.1016/j.fertnstert.2023.05.170

Balogh O, Szilágyi E, Balogh N, Somogyi Z, Müller L. Half-life of serum anti-Müllerian hormone and changes after gonadectomy in adult female and male dogs with normal and abnormal gonads. Theriogenology. 2024 Mar 15;217:18-24. https://doi.org/10.1016/j.theriogenology.2024.01.004

Yang PK, Chou CH, Huang CC, Wen WF, Chen HF, Shun CT, et al. Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production. Mol Metab. 2021 Jul 1;49:101189. https://doi.org/10.1016/j.molmet.2021.101189

Di Clemente N, Racine C, Pierre A, Taieb J. Anti-Müllerian hormone in female reproduction. Endocr Rev. 2021 Dec 1;42(6):753-82. https://doi.org/10.1210/endrev/bnab012

Cedars MI. Evaluation of female fertility-AMH and ovarian reserve testing. J Clin Endocrinol Metab. 2022 Jun 1;107(6):1510-9. https://doi.org/10.1210/clinem/dgac039

Wiles K, Anckaert E, Holden F, Grace J, Nelson-Piercy C, Lightstone L, et al. Anti-Müllerian hormone concentrations in women with chronic kidney disease. Clin Kidney J. 2021;14(2):537-42. https://doi.org/10.1093/ckj/sfz164

Kloos J, Perez J, Weinerman R. Increased body mass index is negatively associated with ovarian reserve as measured by anti-Müllerian hormone in patients with polycystic ovarian syndrome. Clin Obes. 2024;14(3):e12638. https://doi.org/10.1111/cob.12638

Al Wattar BH, Fisher M, Bevington L, Talaulikar V, Davies M, Conway G, et al. Clinical practice guidelines on the diagnosis and management of polycystic ovary syndrome: a systematic review and quality assessment study. J Clin Endocrinol Metab. 2021 Aug 1;106(8):2436-46. https://doi.org/10.1210/clinem/dgab232

Li YL, Yan EQ, Zhao GN, Jin L, Ma BX. Effect of body mass index on ovarian reserve and ART outcomes in infertile women: a large retrospective study. J Ovarian Res. 2024;17(1):195. https://doi.org/10.1186/s13048-024-01521-1

Buyukkaba M, Turgut S, Ilhan MM, Ekinci I, Yaylım İ, Zeybek SU, Turan S, Tasan E, Karaman O. Anti-Müllerian hormone levels increase after bariatric surgery in obese female patients with and without polycystic ovary syndrome. Horm Metab Res. 2022 Mar;54(3):194-8. https://doi.org/10.1055/a-1756-4798

Mehrabani S, Arab A, Karimi E, Nouri M, Mansourian M. Blood circulating levels of adipokines in polycystic ovary syndrome patients: a systematic review and meta-analysis. Reprod Sci. 2021 Nov;28(11):3032-50. https://doi.org/10.1007/s43032-021-00709-w

Islam UN, Begum A, Rahman F, Haq MA, Kumar S, Chowdhury K, et al. The relationship between serum anti-Müllerian hormone and basal antral follicle count in infertile women under 35 years: an assessment of ovarian reserve. Cureus. 2023;15(12). https://doi.org/10.7759/cureus.50181

Albu D, Albu A. The relationship between anti-Müllerian hormone serum level and body mass index in a large cohort of infertile patients. Endocrine. 2019;63:157-63. https://doi.org/10.1007/s12020-018-1756-4

DOI: https://doi.org/10.46903/gjms/23.1.1847