MATERNAL SERUM LIPID PROFILE AND RISK OF PREECLAMPSIA AMONG PREGNANT WOMEN

Wajeeha Syed; Nazish Hayat; Sajida Bibi; Tayyaba Bibi

doi:10.46903/gjms/22.01.1547

MATERNAL SERUM LIPID PROFILE AND RISK OF PREECLAMPSIA AMONG PREGNANT WOMEN

Wajeeha Syed, Nazish Hayat, Sajida Bibi, Tayyaba Bibi

Abstract

Background: Preeclampsia, a hypertensive disorder of pregnancy,develops after 20 weeks of gestation and is characterized by proteinuria and hypertension. It affects 3% to 8% pregnant population worldwide, with significant morbidity and mortality. The etiology of pre-eclampsia is not well understood, and various factors have been speculated to be involved in the disease process. The objective of this study was to determine the association between maternal serum lipid profile and preeclampsia among antenatal patients presented to a tertiary care hospital.

Materials & Methods: It was cross-sectional observational study, conducted at the gynecology department of Lady Reading Hospital in Peshawar, from October 2022 to April 2023. A total sample of 100 pregnant women was recruited by non-probability consecutive sampling technique. Inclusion criteria was antenatal patients with singleton pregnancy, including both normotensive and pre-eclamptic patients. Patients with multiple pregnancy, chronic hypertension, renal and autoimmune diseases, liver disorders, recent viral infections history, blood disorders and body mass index more than 30kg/m2 were excluded from the study. Lipid profile parameters (total cholesterol, LDL, HDL, and triglycerides) and BMI were measured. Statistical analysis included descriptive statistics and independent t-tests were used.

Results: The mean age of the participants was 26.9 years and the SD was ±5.58045. Participants with preeclampsia (n =38) showed elevated levels of total cholesterol (262.89±89.77 mg/dl) and association with preeclampsia was significant (p-value=0.004). LDL (197.11±80.55 mg/dl) and Triglycerides levels (426.34±504.74 mg/dl) were also higher in pre-eclamptics and association was significant (p-value 0.007 and 0.005 respectively). However, HDL levels (49.37±19.74 mg/dl) didn’t exhibit a significant association(p=0.075).

Conclusion: This study found a significant association between elevated maternal serum total cholesterol, LDL, and triglyceride levels with the risk of preeclampsia. Identifying these lipid profile alterations helps in early diagnosis and management of preeclampsia, potentially leading to better outcomes for both the mother and the fetus.

Keywords

Lipids; Blood; Preeclampsia; Cholesterol; LDL.

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References

Tesfa E, Nibret E, Munshea A. Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis. PLoS ONE 2020;15(12):e0243538. https://doi.org/10.1371/journal.pone.0243538

Jenabi E, Afshari M, Khazaei S. The association between preeclampsia and the risk of metabolic syndrome after delivery: a meta-analysis. J Matern Fetal Neonatal Med 2021;34(19):3253-8. https://doi.org/10.1080/14767058.2019.1678138

Ebogo-Belobo J-T, Bilongo CM, Voufo RA, Atembeh-Noura E, Djabidatou O, Kenfack MT, et al. Maternal serum lipids in some women with pre-eclampsia in Yaoundé. Pan Afr Med J 2021;39(1). https://doi.org/10.11604/pamj.2021.39.14.22734

Saif A, Rizwan W, Durrani H, Iqbal K, Baloch K, Shami N. Frequency of Pregnancy Induced Hypertension in pregnant patients presenting in a tertiary care hospital and Comparison of Serum Lipid Profile in Normotensive and Hypertensive Pregnant Women. Pak J Med Sci 2020;14(2):336-9.

Avidime AR, Tella MA, Hadiza G, Abiodun OO. A comparative Study of Serum Lipid Levels in Pre-Eclamptic and Normotensive Pregnant Women in a Tertiary Hospital, Northwest Nigeria Biomed 2018;3(1):3003-11. https://doi.org/10.26717/BJSTR.2018.03.000845

Ardalić D, Stefanović A, Banjac G, Cabunac P, Miljković M, Mandić-Marković V, et al. Lipid profile and lipid oxidative modification parameters in the first trimester of high-risk pregnancies-possibilities for preeclampsia prediction. Clin Biochem 2020;81:34-40. https://doi.org/10.1016/j.clinbiochem.2020.05.003

He B, Liu Y, Maurya MR, Benny P, Lassiter C, Li H, et al. The maternal blood lipidome is indicative of the pathogenesis of severe preeclampsia. J Lipid R 2021;62. https://doi.org/10.1016/j.jlr.2021.100118

Khaire AA, Thakar SR, Wagh GN, Joshi SR. Placental lipid metabolism in preeclampsia. J Hypertens 2021;39(1):127-34. https://doi.org/10.1097/HJH.0000000000002596

Yadav S, Agrawal M, Hariharan C, Dewani D, Vadera K, Krishna N. A comparative study of serum lipid profile of women with preeclampsia and normotensive pregnancy. J DMIMU 2018;13(2):83-6. https://doi.org/10.4103/jdmimsu.jdmimsu_70_17

Jasovic-Siveska E, Milkovski D. Maternal plasma lipid concentration in first and second trimester of pregnancy and risk of preeclampsia. Obstet Gynecol Int J. 2019;10(4):299-304. https://doi.org/10.15406/ogij.2019.10.00458

Jan S, Nawaz S. Serum lipid levels in pregnant women complicated by pre-eclampsia. Rawal Med J. 2021;46(4):873. Available at: https://www.researchgate.net

Faraji A, Razavi B, Zare M. Values of First and Early Third Trimesters Serum Lipid Profile in the Prediction of Preeclampsia: A Cohort Study. GMJ 2022;11:e2395 https://doi.org/:10.31661/gmj.v11i.2395

Mou AD, Barman Z, Hasan M, Miah R, Hafsa JM, Trisha AD, et al. Prevalence of preeclampsia and the associated risk factors among pregnant women in Bangladesh. Sci Rep 2021;11:21339. https://doi.org/10.1038/s41598-021-00839-w

Salma U. Relationship of serum lipid profiles in preeclampsia and normal pregnancy, Bangladesh. Afr Health Sci 2022;22(2):475. https://doi.org/10.4314/ahs.v22i2.55

Thathagari V, Veerendra KC. Evaluation of serum lipids in preeclampsia: a comparative study. Int J Reprod Contracept Obstet Gynecol 2018;7(4):1372-76. https://doi.org/10.18203/2320-1770.ijrcog20180998

Faraji A, Razavi B, Zare M. Hypertensive Pregnancy Disorders and Lipid Profiles: A Cohort Study. GMJ 2022;11:e2395-e. https://doi.org/10.31661/gmj.v11i.2395

DOI: https://doi.org/10.46903/gjms/22.01.1547