Email this article COMPARISON OF EFFECTIVENESS OF GABAPENTIN AND SODIUM VALPROATE IN PATIENTS WITH MIGRAINE
Abstract
Background: Migraine causes patients’ disability so that these patients are either absent from work and study, or even if they attend, they do not have the necessary efficiency for learning or working. Objectives of the study was to compare the effects of gabapentin (GBP) and sodium valproate (VPA) on patients with migraine headaches.
Materials & Methods: In this clinical trial, patients suffering from migraine were included in the study and received preventive treatments of migraine in two groups: GBP (n=35) and VPA (n=35). In this study, headache impact test (HIT6) and Migraine Disability Assessment Scale (MIDAS) were used. the sampling method is block random and in the order of patients entering the department, they are in group A (GBP) and B (sodium VPA) and the sampling continued until the patients reached a sample size of n=70. In all patients, 6 and 12 weeks after taking the drugs, MHA was examined using HIT6 and MIDAS. the data were analyzed by SPSS 16.
Results: Results showed, HIT6 score reduced from 53.68 (8.98) to 42.02 (2.61) in GBP group, and reduced from 55.57 (9.24) to 41.91 (2.17) in VAP group. MIDAS score reduced from 14.28 (1.5) to 5.97 (1.12) in GBP group and reduced from 14.85 (3.39) to 6.4 (1.11) in VAP group. Also, in the group receiving GBP, HIT6 score reduced significantly (P=0.000, F=3960.727) and MIDAS score also reduced significantly (P=0.000, F=5509.340). Also, in VAP group, a significant reduction was found in HIT6 (P=0.000, F=4855.349) and MIDAS (P=0.000, F=1332.999)
Conclusions: Both GBP and VPA reduced MHA. For this reason, while suggesting the prescription of both of these drugs, it is suggested to conduct further studies in this field.
Keywords
Full Text:
PDFReferences
Society HCSotIH. The international classification of headache disorders. cephalalgia. 2004; 24:1-160.
Charles A. The pathophysiology of migraine: implications for clinical management. The Lancet Neurology. 2018;17(2):174-82. https://doi.org/10.1016/S1474-4422(17)30435-0
Vasigh A, Tarjoman A, Soltani B, Borji M. The relationship between mindfulness and self-compassion with perceived pain in migraine patients in Ilam, 2018. Archives of Neuroscience. 2019;6(3). https://doi.org/10.5812/ans.91623
Tarjoman A, Borji M, Safari S, Otaghi M. Investigating the effects of adaptive stability model on headache of patients with migraine. Archives of neuroscience. 2019;6(1). https://doi.org/10.5812/ans.81492
Sadeghian H, Karimzadeh F, Jafarian M. Mechanisms Involved in Pathophysiology of Different Types of Migraines. The Neuroscience Journal of Shefaye Khatam. 2013;1(4):50-4. https://doi.org/10.18869/acadpub.shefa.1.4.50
Kim Y, Han S, Suh HS. The impact of migraine and probable migraine on productivity loss in Korea: A cross-sectional online survey. Plos one. 2022;17(11):e0277905. https://doi.org/10.1371/journal.pone.0277905
Wong LP, Alias H, Bhoo-Pathy N, Chung I, Chong YC, Kalra S, et al. Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia. The journal of headache and pain. 2020;21(1):1-11. https://doi.org/10.1186/s10194-020-01144-z
Wong LP, Alias H, Bhoo-Pathy N, Chung I, Chong YC, Kalra S, et al. Impact of migraine on workplace productivity and monetary loss: a study of employees in banking sector in Malaysia. The Journal of Headache and Pain. 2020;21(1):68. https://doi.org/10.1186/s10194-020-01144-z
Garramone F, Baiano C, Russo A, D'Iorio A, Tedeschi G, Trojano L, et al. Personality profile and depression in migraine: a meta-analysis. Neurological Sciences. 2020;41(3):543-54. https://doi.org/10.1007/s10072-019-04174-x
Bhurgri GR, Buksh H, Qureshi MA. Frequency of depression in migraine patients. Gomal Journal of Medical Sciences. 2009;7(2).
Baradaran M, M AA, A, Teymourian F, Alinezhad F, Moghadamnia A. Concomitant Administration of Alprazolam and Ibuprofen in Acute Migraine Headache. Journal of Babol University of Medical Sciences. 2011;13(3):15-21.
Noamesi AT, Olokede OA, De La Cruz N, Appiah D. The role of mental health and substance use disorders on the relation of migraine with self-directed violence among women in the United States. Journal of psychosomatic research. 2023;165:111120. https://doi.org/10.1016/j.jpsychores.2022.111120
Al-Hayani M, AboTaleb H, Bazi A, Alghamdi B. Depression, anxiety and stress in Saudi migraine patients using DASS-21: local population-based cross-sectional survey. International Journal of Neuroscience. 2023;133(3):248-56. https://doi.org/10.1080/00207454.2021.1909011
Wenzel RG, Sarvis CA, Krause ML. Over-the-counter drugs for acute migraine attacks: Literature review and recommendations. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2003;23(4):494-505. https://doi.org/10.1592/phco.23.4.494.32124
Azami-Aghdash S, Mohseni M, Etemadi M, Royani S, Moosavi A, Nakhaee M. Prevalence and Cause of Self-Medication in Iran: A Systematic Review and Meta-Analysis Article. Iran J Public Health. 2015;44(12):1580-93.
Fruth B, Ikombe NB, Matshimba GK, Metzger S, Muganza DM, Mundry R, et al. New evidence for self-medication in bonobos: Manniophyton fulvum leaf- and stemstrip-swallowing from LuiKotale, Salonga National Park, DR Congo. Am J Primatol. 2014;76(2):146-58. https://doi.org/10.1002/ajp.22217
Nguyen HV, Nguyen TH. Factors associated with self-medication among medicine sellers in urban Vietnam. Int J Health Plann Manage. 2015;30(3):219-31. https://doi.org/10.1002/hpm.2223
Saha A, Marma KKS, Rashid A, Tarannum N, Das S, Chowdhury T, et al. Risk factors associated with self-medication among the indigenous communities of Chittagong Hill Tracts, Bangladesh. Plos one. 2022;17(6):e0269622. https://doi.org/10.1371/journal.pone.0269622
Zeb S, Mushtaq M, Ahmad M, Saleem W, Rabaan AA, Naqvi BSZ, et al. Self-Medication as an Important Risk Factor for Antibiotic Resistance: A Multi-Institutional Survey among Students. Antibiotics. 2022;11(7):842. https://doi.org/10.3390/antibiotics11070842
Edet CK, Wegbom AI, Samuel KG, Sapira-Ordu L, Jaja ID, Ene-Peter J, et al. Prevalence and Factors Influencing Self-Medication among Pregnant Women Attending Antenatal Clinics in Urban Tertiary Hospitals in Nigeria. BioMed. 2023;3(1):166-76. https://doi.org/10.3390/biomed3010014
Perrot S, Cittée J, Louis P, Quentin B, Robert C, Milon JY, et al. Self-medication in pain management: The state of the art of pharmacists' role for optimal Over-The-Counter analgesic use. European Journal of Pain. 2019;23(10):1747-62. https://doi.org/10.1002/ejp.1459
Hatefi M, Abdi A, Tarjoman A, Borji M. Prevalence of depression and pain among patients with spinal cord injury in Iran: A systematic review and meta-analysis. Trauma Monthly. 2019;24(4):1-8. https://doi.org/10.5812/traumamon.87503
Vasigh A, Tarjoman A, Borji M. The effect of spiritual-religious interventions on patients' pain status: Systematic review. Anaesthesia, Pain & Intensive Care. 2018;22(4).
Dogruyol S, Gur STA, Akbas I, Kocak MB, Kocak AO, Ceylan M, et al. Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department: A randomized clinical trial. The American Journal of Emergency Medicine. 2022;55:126-32. https://doi.org/10.1016/j.ajem.2022.02.046
Hatefi M, Komlakh K. Investigating the effect of methylprednisolone pulse on treatment of back pain. Eurasian Chemical Communications. 2022;4(5):366-71.
Hatefi M, KomLakh K. Investigation of the effect of Duloxetine on pain status of patients with spinal cord injuries: A systematic review of drug therapy. Eurasian Chemical Communications. 2022;4(3):256-62.
LIANG J, WEI Y, LU M, LIANG J, JIANG L, ZHAO L. Clinical efficacy of gabapentin or topiramate combined with venlafaxine in the treatment of chronic migraine with anxiety disorder. Chinese Journal of Postgraduates of Medicine. 2021:243-8.
Wang F, Zhang H, Wang L, Cao Y, He Q. Intravenous sodium valproate for acute migraine in the emergency department: A meta-analysis. Acta Neurologica Scandinavica. 2020;142(6):521-30. https://doi.org/10.1111/ane.13325
Khani S, Hejazi SA, Yaghoubi M, Sharifipour E. Comparative study of magnesium, sodium valproate, and concurrent magnesium-sodium valproate therapy in the prevention of migraine headaches: a randomized controlled double-blind trial. The Journal of Headache and Pain. 2021;22(1):21. https://doi.org/10.1186/s10194-021-01234-6
Cutrer FM, Limmroth V, Moskowitz MA. Possible mechanisms of valproate in migraine prophylaxis. Cephalalgia. 1997;17(2):93-100. https://doi.org/10.1046/j.1468-2982.1997.1702093.x
Parikh SK, Silberstein SD. Current Status of Antiepileptic Drugs as Preventive Migraine Therapy. Current Treatment Options in Neurology. 2019;21(4):16.https://doi.org/10.1007/s11940-019-0558-1
Ramabadran A, Desai V, Longtin W, Palutla L, Bezaire M. The Effects of Gabapentin on Epileptic Seizures: A Computational Model. Journal of Student Research. 2022;11(4). https://doi.org/10.47611/jsr.v11i4.1791
Amiri S, Haj-Mirzaian A, Amini-Khoei H, Razmi A, Shirzadian A, Rahimi-Balaei M, et al. Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice. European Journal of Pharmacology. 2017;797:106-14. https://doi.org/10.1016/j.ejphar.2017.01.024
Magnoux E, Freeman MA, Zlotnik G. MIDAS and HIT-6 French translation: reliability and correlation between tests. Cephalalgia. 2008;28(1):26-34. https://doi.org/10.1111/j.1468-2982.2007.01461.x
Sauro KM, Rose MS, Becker WJ, Christie SN, Giammarco R, Mackie GF, et al. HIT-6 and MIDAS as measures of headache disability in a headache referral population. Headache: The Journal of Head and Face Pain. 2010;50(3):383-95. https://doi.org/10.1111/j.1526-4610.2009.01544.x
Dikmen PY, Bozdağ M, Güneş M, Koşak S, Taşdelen B, Uluduz D, et al. Reliability and validity of Turkish version of Headache Impact Test (HIT-6) in patients with migraine. Archives of Neuropsychiatry. 2021;58(4):300.
Hjermstad MJ, Fayers PM, Haugen DF, Caraceni A, Hanks GW, Loge JH, et al. Studies comparing numerical rating scales, verbal rating scales, and visual analogue scales for assessment of pain intensity in adults: a systematic literature review. Journal of pain and symptom management. 2011;41(6):1073-93. https://doi.org/10.1016/j.jpainsymman.2010.08.016
Najafi MR, Ghorbani A, Sonbolestan SA, Abdi R. The effect of topiramate in improvement of migraineurs' clinical status a clinical trial. Pejouhesh dar Pezeshki (Research in Medicine). 2011;35(3):141-6.
Yang M, Rendas-Baum R, Varon SF, Kosinski M. Validation of the Headache Impact Test (HIT-6™) across episodic and chronic migraine. Cephalalgia. 2011;31(3):357-67. https://doi.org/10.1177/0333102410379890
Farhadi Z, Alidoost S, Behzadifar M, Mohammadibakhsh R, Khodadadi N, Sepehrian R, et al. The Prevalence of Migraine in Iran: A Systematic Review and Meta-Analysis. Iran Red Crescent Med J. 2016;18(10):e40061. https://doi.org/10.5812/ircmj.40061
Sadeghi O, Nasiri M, Saiedi SG. The Prevalence of Migraine in Different Parts of Iran: Review of the Current Evidence. 2015;4(3):e27678. https://doi.org/10.5812/jjcdc.4(3)2015.27678
Karimiyarandi H, Karbasfrushan A. EFFECT OF DULOXETINE ON PAIN RELIEF IN PATIENTS UNDERGOING ARTHROPLASTY SURGERY: A SYSTEMATIC REVIEW. Gomal Journal of Medical Sciences. 2022;20(4):213-20.
Humayun F, Mujtaba G, Seerwan M, Khan G, Javed N, Adnan M. EFFICACY OF ALFUZOSIN VERSUS CONTROL GROUP IN UPPER URETERIC STONE EXPULSION IN ADULT POPULATION OF LAHORE, PAKISTAN. Gomal Journal of Medical Sciences. 2021;19(4). https://doi.org/10.46903/gjms/19.04.904
Zain S, Khan M, Alam R, Zafar I, Ahmed S. Comparison of efficacy and safety of topiramate with gabapentin in migraine prophylaxis: randomized open label control trial. J Pak Med Assoc. 2013;63(1):3-7.
Gholami H, Motamed N, Hojatansari M, Hushmandpur F. Comparison the Effect of Gabapentin and Theophylline on Post Spinal Headache After Cesarean Section. Journal of Advances in Medical and Biomedical Research. 2021;29(136):251-6. https://doi.org/10.30699/jambs.29.136.251
Amanat M, Togha M, Agah E, Ramezani M, Tavasoli AR, Azizi Malamiri R, et al. Cinnarizine and sodium valproate as the preventive agents of pediatric migraine: A randomized double-blind placebo-controlled trial. Cephalalgia. 2020;40(7):665-74. https://doi.org/10.1177/0333102419888485
Serdaroglu G, Erhan E, Tekgul H, Oksel F, Erermis S, Uyar M, et al. Sodium valproate prophylaxis in childhood migraine. Headache: The Journal of Head and Face Pain. 2002;42(8):819-22. https://doi.org/10.1046/j.1526-4610.2002.02186.x
Bidabadi E, Mashouf M. A randomized trial of propranolol versus sodium valproate for the prophylaxis of migraine in pediatric patients. Pediatric Drugs. 2010;12:269-75. https://doi.org/10.2165/11316270-000000000-00000
Ünalp A, Uran N, Öztürk A. Comparison of the effectiveness of topiramate and sodium valproate in pediatric migraine. Journal of child neurology. 2008;23(12):1377-81. https://doi.org/10.1177/0883073808318547
Pavitt S, Gelfand AA, Zorrilla N, Allen I, Riggins N. Efficacy and Safety of Repetitive Intravenous Sodium Valproate in Pediatric Patients With Refractory Chronic Headache Disorders: A Retrospective Review. Pediatric Neurology. 2022;128:52-7. https://doi.org/10.1016/j.pediatrneurol.2021.12.008
Shahien R, Saleh S, Bowirrat A. Intravenous sodium valproate aborts migraine headaches rapidly. Acta neurologica scandinavica. 2011;123(4):257-65. https://doi.org/10.1111/j.1600-0404.2010.01394.x
Rahimdel A, Zeinali A, Yazdian-Anari P, Hajizadeh R, Arefnia E. Effectiveness of Vitamin B2 versus Sodium Valproate in Migraine Prophylaxis: a randomized clinical trial. Electron Physician. 2015;7(6):1344-8.
Hesami O, Shams MR, Ayazkhoo L, Assarzadegan F, Safarpour Lima B, Delavar Kasmaei H, et al. Comparison of Pregabalin and Sodium Valproate in Migraine Prophylaxis: A Randomized Double-Blinded Study. Iran J Pharm Res. 2018;17(2):783-9.
Hesami O, Shams MR, Ayazkhoo L, Assarzadegan F, Safarpour Lima B, Delavar Kasmaei H, Sistanizad M. Comparison of Pregabalin and Sodium Valproate in Migraine Prophylaxis: A Randomized Double-Blinded Study. Iran J Pharm Res. 2018 Spring;17(2):783-789. PMID: 29881434; PMCID: PMC5985194.
Choudhary MU, Nawaz J, Saddique MU, Zameer A. Comparison between topiramate and sodium valproate efficacy in the treatment of migraine. Pak J Med Health Sci. 2017 Jul 1;11(3):1005-7.
Rahimdel AGh, Mellat A, Zeinali A, Jafari E, Ayatollahi P. Comparison between Intravenous Sodium Valproate and Subcutaneous Sumatriptan for Treatment of Acute Migraine Attacks; Double-Blind Randomized Clinical Trial. Iran J Med Sci. 2014;39(2):171-177.
DOI: https://doi.org/10.46903/gjms/22.01.1329
Refbacks
- There are currently no refbacks.
Copyright (c) 2024. elham bastani
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Gomal Medical College, Daraban Road, Dera Ismail Khan, Pakistan
ISSN: 1819-7973, e-ISSN: 1997-2067
Website: https://www.gmcdikhan.edu.pk
Phone: +92-966-747373
