CAN WE REDEFINE VITAMIN D DEFICIENCY?

Muhammad Shabbir

doi:10.46903/gjms/20.04.1239

CAN WE REDEFINE VITAMIN D DEFICIENCY?

Muhammad Shabbir

Abstract

Majority of the world population is vitamin D deficient based on its current definition for deficiency. But despite being deficient, most of the physiological and biochemical parameters related to vitamin D deficiency, namely serum calcium, alkaline phosphatase and serum parathyroid hormone (PTH) remains normal. Serum PTH should rise up as a physiological feedback in response to vitamin D low levels. But the inflection point of PTH occurs at much lower levels of vitamin D (15ng/dL) than at the currently defined cut-off for deficiency (20ng/dL). Can we redefine vitamin D deficiency taking into account the vitamin D-PTH coupled testing and considering the PTH rise/ inflection as the appropriate response to low vitamin D level?

Keywords

Vitamin D; Vitamin D deficiency; Rickets; Parathyroid Hormone; Calcium; Alkaline Phosphatase.

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References

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DOI: https://doi.org/10.46903/gjms/20.04.1239