HYPOLIPIDEMIC AND HYPOGLYCEMIC ACTIVITY OF MEDICINAL PLANTS IN STZ (STREPTOZOTOCIN) INDUCED HYPERLIPIDEMIC RATS AND THEIR ROLE IN HEALTH AND DISEASE

Farah Naz Tahir; Hania Ali; Iqra Taqi

doi:10.46903/gjms/20.01.1078

HYPOLIPIDEMIC AND HYPOGLYCEMIC ACTIVITY OF MEDICINAL PLANTS IN STZ (STREPTOZOTOCIN) INDUCED HYPERLIPIDEMIC RATS AND THEIR ROLE IN HEALTH AND DISEASE

Farah Naz Tahir, Hania Ali, Iqra Taqi

Abstract

In the past few years, medical plants research focused on a lot by scientists all over the world. Many evidence has been studied to show the potential effects of medicinal plants in the medical field. This is due to the presence of many metabolites in plants that includes flavonoids, tannins, terpenoids, and many hypolipidemic and hypoglycemic agents.

This study aims to evaluate various medicinal plants for anti-diabetic and hypolipidemic activity in rats. Diabetes mellitus is one of the most common non communicable diseases present globally and it’s most lethal complication which developed is dyslipidemia which ultimately leads to cardiovascular events which are hard to control and it’s not possible to revert back its effects. Since ancient times plants have been the source of medicine. Many kinds of literature mentioned the use of plants in the treatment of various diseases. This review covers the anti-diabetic and antihyperlipidemic effects of medicinal plants. Investigation of phytochemicals present in medicinal plants and their biological activities are reported. The hypolipidemic activity which is present in most medicinal plants is strongly associated with new drug development which will be used for high lipid profiles and cardiovascular disease.

Keywords medicinal plants, anti-diabetic, hypolipidemic, cardiovascular events, STZ (Streptozotocin).

Keywords

HYPOLIPDEMIC, ANTI DIABETIC

Full Text:

PDF

References

Goodman G, Hardman J, Limbird L, Goodman GA. Insulin, Oral Hypoglycaemic agents and the pharmacology of endocrine pancreas. Pharmacol Basis Ther. 2006;60:1686-710.

Islam D, Huque A, Sheuly S, Chandra Mohanta L, Kumar Das S, Sultana A, et al. Hypoglycemic and hypolipidemic effects of Nelumbo nucifera flower in Long-Evans rats.JHP. 2018;7(3).

Rahimi-Madiseh M, Karimian P, Kafeshani M, Rafieian-Kopaei M. The effects of ethanol extract of Berberis vulgaris fruit on histopathological changes and biochemical markers of the liver damage in diabetic rats. IJBMS 2017;20(5):552.

Maideen NMP, Balasubramaniam R. Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs. Journal of Herbmed Pharmacology. 2018;7(3).

Boyle JP, Honeycutt AA, Narayan KV, Hoerger TJ, Geiss LS, Chen H, et al. Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the US. Diabetes Care. 2001;24(11):1936-40.

Kavishankar G, Lakshmidevi N, Murthy SM, Prakash H, Niranjana S. Diabetes and medicinal plants-A review. Int J Pharm Biomed Sci. 2011;2(3):65-80.

Mohammed A, Ibrahim MA, Islam MS. African medicinal plants with antidiabetic potentials: A review. Planta Medica. 2014;80(05):354-77.

Graham JE, Stoebner-May DG, Ostir GV, Al Snih S, Peek MK, Markides K, et al. Health-related quality of life in older Mexican Americans with diabetes: a cross-sectional study. Health and Quality of Life Outcomes. 2007;5(1):39.

Dey L, Attele AS, Yuan C-S. Alternative therapies for type 2 diabetes. Alternative medicine review. 2002;7(1):45-58.

Jamshidi-Kia F, Lorigooini Z, Amini-Khoei H. Medicinal plants: Past history and future perspective. Journal of herbmed pharmacology. 2018;7(1).

Asadi‐Samani M, Bagheri N, Rafieian‐Kopaei M, Shirzad H. Inhibition of Th1 and Th17 cells by medicinal plants and their derivatives: a systematic review. Phytotherapy Research. 2017;31(8):1128-39.

Karami S, Roayaei M, Hamzavi H, Bahmani M, Hassanzad-Azar H, Leila M, et al. Isolation and identification of probiotic Lactobacillus from the local dairy and evaluating their antagonistic effect on pathogens. IJPI. 2017;7(3):137.

Rabiei Z, Gholami M, Rafieian-Kopaei M. Antidepressant effects of Mentha pulegium in mice. Bangladesh J Pharmacol. 2016;11(3):711-5.

Cragg GM, Newman DJ. Natural products: a continuing source of novel drug leads. Biochimica et Biophysica Acta (BBA)-General Subjects. 2013;1830(6):3670-95.

Day C. Traditional plant treatments for diabetes mellitus: pharmaceutical foods. British Journal of Nutrition. 1998;80(1):5-6.

Ibrahim AM. The in vitro and in vivo anti-oxidative and anti-diabetic effects of some African medicinal plants and the identification of the bioactive compounds 2013.

Viktorinova A, Svitekova K, Stecova A, Krizko M. Relationship between selected oxidative stress markers and lipid risk factors for cardiovascular disease in middle-aged adults and its possible clinical relevance. Clinical biochemistry. 2016;49(12):868-72.

Siti HN, Kamisah Y, Kamsiah J. The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vascular pharmacology. 2015;71:40-56.

Wadhera RK, Steen DL, Khan I, Giugliano RP, Foody JM. A review of low-density lipoprotein cholesterol, treatment strategies, and its impact on cardiovascular disease morbidity and mortality. Journal of clinical lipidology. 2016;10(3):472-89.

Kühnast S, Fiocco M, van der Hoorn JW, Princen HM, Jukema JW. Innovative pharmaceutical interventions in cardiovascular disease: focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raising systematic review and meta-analysis of relevant preclinical studies and clinical trials. European journal of pharmacology. 2015;763:48-63.

Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. European heart journal. 2011;32(11):1345-61.

Gardener H, Wright CB, Cabral D, Scarmeas N, Gu Y, Cheung K, et al. Mediterranean diet and carotid atherosclerosis in the Northern Manhattan Study. Atherosclerosis. 2014;234(2):303-10.

Schauer N, Fernie AR. Plant metabolomics: towards biological function and mechanism. Trends in plant science. 2006;11(10):508-16.

Lefebvre P. Diabetes yesterday, today and tomorrow. The action of the International Diabetes Federation. Revue medicale de Liege. 2005;60(5-6):273-7.

Hayat A, shaikh N. Barriers and Myths to initiate insulin therapy for type 2 diabetes mellitus at primary health care centers of Hyderabad district. World Applied Sciences Journal. 2010;08:66-72.

Salpeter S, Greyber E, Pasternak G, Salpeter E. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus (Withdrawn paper, art. no. CD002967, 2006). COCHRANE DATABASE OF SYSTEMATIC REVIEWS. 2006(1).

Singh S, Loke YK, Furberg CD. Thiazolidinediones and heart failure: a teleo-analysis. Diabetes Care. 2007;30(8):2148-53.

Hegazy GA, Alnoury AM, Gad HG. The role of Acacia Arabica eextractsas an antidiabetic, antihyperlipidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi Med J. 2013;34(7):727-33.

Gupta PD, De A. Diabetes Mellitus, and its herbal treatment. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012;3(2):706-21.

Kumar A, Gnananath K, Gande S, Goud E, Rajesh P, Nagarjuna S. Anti-diabetic Activity of Ethanolic Extract of Achyranthes Aspera Leaves in Streptozotocin-induced diabetic rats. Journal of Pharmacy Research. 2011;4(7):3124-5.

Wiedenfeld H, Andrade-Cetto A. Hypoglycemic effect of Acosmium panamense bark on streptozotocin-diabetic rats. 2004.

Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine. 2006;13(9-10):624-9.

Shinde V, Borkar A, Badwaik R. Evaluation and comparative study of hypoglycemic activity of aloe Barbadensis Miller with oral hypoglycemic drugs (glibenclamide and metformin) in rats. International Journal of Medical Research and Pharmaceutical Sciences. 2014;4:31-6.

SM A-SLA-K, Twaiji H. Hypoglycemic effect of Artemisia herba alba II. Effect of a valuable extract n some blood parameters in diabetic animals J EthnoPharmacol. 1994;43:167.

Espósito AM, Diaz A, De Gracia I, De Tello R, Gupta M. Evaluation of traditional medicine: effects of Cajanus cajan L. and of Cassia fistula L. on carbohydrate metabolism in mice. Revista medica de Panama. 1991;16(1):39.

Puri D. The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: a preliminary experimental study. Journal of ethnopharmacology. 2001;78(1):89-93.

Anand P, Murali K, Tandon V, Chandra R, Murthy P. Preliminary studies on antihyperglycemic effect of aqueous extract of Brassica nigra (L.) Koch in streptozotocin induced diabetic rats. 2007.

Ahangarpour A, Oroojan A. Effect of crust and seed hydro-alcoholic and aqueous extracts and pulp hydro-alcoholic extract of Citrullus colocynthis on glucose, insulin and FIRI level in insulin resistant male rat’s. The Horizon of Medical Sciences. 2013;19(3):149-54.

Kadir M, Al-Snafi A, Farman N. Comparison between the efficacy of sulfur and garlic in the treatment of scabies. The Med J Tikrit University. 1999;5:122-5.

Al-Snafi AE. Therapeutic properties of medicinal plants: a review of their detoxification capacity and protective effects (part 1). Asian Journal of Pharmaceutical Science & Technology. 2015;5(4):257-70.

Al-Snafi AE. Chemical constituents and pharmacological importance of Agropyron repens–A review. Research Journal of Pharmacology and Toxicology. 2015;1(2):37-41.

Al-Snafi AE. Therapeutic properties of medicinal plants: a review of their immunological effects (part 1). Asian Journal of Pharmaceutical Research. 2015;5(3):208-16.

Rajasree C, Rajamohan T, Augusti K. Biochemical effects of garlic protein on lipid metabolismalcohol-fed fed rats. 1999.

Bordia A. Effect of garlic on blood lipids in patients with coronary heart disease. The American journal of clinical nutrition. 1981;34(10):2100-3.

Kojuri J, Vosoughi AR, Akrami M. EffectsAnethumthum graveolens and garlic on lipid profile in hyperlipidemic patients. Lipids in Health and Disease. 2007;6(1):1-5.

Kim K, Kim H, Kwon J, Lee S, Kong H, Im S-A, et al. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. Phytomedicine. 2009;16(9):856-63.

Jantan I, Rafi I, Jalil J. Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. Phytomedicine. 2005;12(1-2):88-92.

Bahramikia S, Yazdanparast R. Improvement of liver antioxidant statushypercholesterolemicamic rats treated wAnethumthum graveolens extracts. Pharmacol online. 2007;3:119-32.

Yazdanparast R, Alavi M. Antihyperlipidaemic and antihypercholesterolaemic effects of Anethum graveolens leaves after the removal of furocoumarins. Cytobios. 2001;105(410):185.

Yazdanparast R, Bahramikia S. Evaluation of the effect of Anethum graveolens L. crude extracts on serum lipids and lipoproteins profiles in hypercholesterolaemic rats. DARU Journal of Pharmaceutical Sciences. 2008;16(2):88-94.

Tsi D, Tan BK. The mechanism underlying the hypocholesterolaemic activity of aqueous celery extract, its butanol and aqueous fractions in genetically hypercholesterolaemic RICO rats. Life sciences. 2000;66(8):755-67.

Mansi K, Abushoffa AM, Disi A, Aburjai T. Hypolipidemic effects of seed extract of celery (Apium graveolens) in rats. Pharmacognosy magazine. 2009;5(20):301.

Ahmed Q, Sayedda K. Effect of celery (Apium graveolens) seeds extract on protease inhibitor (ritonavir) induced dyslipidemia. NJIRM. 2012;3(1):52-6.

Bansode RR, Randolph P, Hurley S, Ahmedna M. Evaluation of hypolipidemic effects of peanut skin-derived polyphenols in rats on Western-diet. Food chemistry. 2012;135(3):1659-66.

Tamura T, Inoue N, Shimizu-Ibuka A, Tadaishi M, Takita T, Arai S, et al. Serum cholesterol reduction by feeding a high-cholesterol diet containing a lower-molecular-weight polyphenol fraction from peanut skin. Bioscience, biotechnology, and biochemistry. 2012:1203292870-.

Zhu X, Zhang W, Pang X, Wang J, Zhao J, Qu W. Hypolipidemic Effect of n‐Butanol Extract from Asparagus officinalis L. in Mice fed a High‐fat Diet. Phytotherapy research. 2011;25(8):1119-24.

Zhu X, Zhang W, Zhao J, Wang J, Qu W. Hypolipidaemic and hepatoprotective effects of ethanolic and aqueous extracts from Asparagus officinalis L. by‐products in mice fed a high‐fat diet. Journal of the Science of Food and Agriculture. 2010;90(7):1129-35.

Kumar D, Parcha V, Maithani A, Dhulia I. Effect and evaluation of antihyperlipidemic activity of fractions of total meth-anol extract of Bauhinia variegata (Linn.) leaves on Triton WR-1339 (Tylox-apol) induced hyperlipidemic rats. International Journal of Research in Pharmaceutical Sciences. 2011;2(4):493-7.

Balamurugan G, Muralidharan P. Antiobesity effect of Bauhinia variegata bark extract on female rats fedthe on hypercaloric diet. ||| Bangladesh Journal of Pharmacology. 2010;5(1):8-12.

Amirthaveni M, Priya V. Hypoglycemic and hypolipidemic effect of ash gourd (Benincasa hispida) and curry leaves (Murraya koenigii). International Journal of Current Research. 2011;3(8):037-42.

DOI: https://doi.org/10.46903/gjms/20.01.1078