THROMBOTIC MICROANGIOPATHIC HEMOLYTIC ANEMIA IN SYSTEMIC LUPUS ERYTHEMATOSUS IN A 25 YEARS OLD FEMALE IN CHENNAI, INDIA

Manimekalai Periyasamy, Pon Divya Bharathi, Mullangi Chenchu Vinatha

Abstract


Systemic lupus erythematosus (SLE) is an autoimmune condition, affecting multiple organs and tissues by autoantibodies and immune complexes. Hematologic manifestations of SLE include anemia, thrombocytopenia and leukopenia. The most common type of anemia seen in SLE is anemia of chronic disease. Thrombotic microangiopathic hemolytic anemia (TMHA) in SLE is very rare. Incidence of TMHA in children with SLE is common compared to adult cases of SLE. Manifestations of TMHA include presence of schistocytes in the peripheral smear, elevated bilirubin levels, elevated LDH and negative coombs test. This case report focuses on 25-year-old female diagnosed concomitantly with SLE and TMHA, and treated with steroids, blood transfusions, megakaryocyte growth factors and antibiotics.

Keywords


Systemic Lupus Erythematosus; Autoantibodies; Anemia; Thrombocytopenia; Leukopenia; Hemolytic Anemia; Microangiopathic Hemolytic Anemia; Hemolytic-Uremic Syndrome; Red Blood Cells; Coombs test.

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References


Kokori SI, Ioannidis JP, Voulgarelis M, Tzioufas AG, Moutsopoulos HM. Autoimmune hemolytic anemia in patients with systemic lupus erythematosus. Am J Med 2000;108:198-204. https://doi.org/10.1016/S0002-9343(99)00413-1

Brain MC, Dacie JV, Hourihane DO. Microangiopathic haemolytic anaemia: the possible role of vascular lesions in pathogenesis. Br J Haematol 1962;8:358-74. https://doi.org/10.1111/j.1365-2141.1962.tb06541.x

Brunner HI, Freedman M, Silverman ED. Close relationship between systemic lupus erythematosus and thrombotic thrombocytopenic purpura in childhood. Arthritis Rheum 1999;42:2346-55. https://doi.org/10.1002/1529-0131(199911)42:11<2346::AID-ANR13>3.0.CO;2-X

Ridolfi RL, Bell WR. Thrombotic thrombocytopenic purpura: report of 25 cases and review of the literature. Medicine (Baltimore) 1981;60:413-28. https://doi.org/10.1097/00005792-198111000-00003

Lewis EJ, Hunsicker LG, Lan SP, Rohde RD, Lachin JM, and the Lupus Nephritis Collaborative Study Group. A controlled trial of plasmapheresis therapy in severe lupus nephritis. N Eng J Med 1992;326:1373-9. https://doi.org/10.1056/NEJM199205213262101




DOI: https://doi.org/10.46903/gjms/19.04.1050

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