Ikechukwu Herbert Egwu, Modesta Mmaduabuchi Egwu-Ikechukwu, Charity Chinyere Nnabugwu, Jamiu Kolawole Mustapha, Chioma Magaret Ali


Background: Uropathogens are group of micro-organisms capable of causing urinary tract infections (UTIs). Treatment of infections due to uropathogens has become difficult because of indiscriminate use of antibiotics and ability to easily acquire resistance mechanisms by these pathogens. The objective of this study was to determine the prevalence and antimicrobial susceptibility profile of bacterial uropathogens implicated in UTI among patients attending the three Mission hospitals in Abakaliki, Ebonyi State of Nigeria.

Materials & Methods: This was a descriptive study done from 1st January 2022 to 30th June 2022, in three Mission Hospitals of Nigeria 1-Rural Improvement Mission hospital, Ikwo (Hospital A); 2-Mater Misrecordea Hospital, Afikpo (Hospital B) and 3- Saint Vincent hospital, Ndubia (Hospital C) and all are located in semi-urban areas of the Ebonyi State. Inclusion criteria were urine samples of both out-patient and admit hospital patients. Both genders of all age groups patients were included. The bacterial isolates were detected using standard microbiological methods and re-confirmed using colonial morphology. Antimicrobial susceptibility profile was performed using Kirby Bauer disc diffusion.

Results: Total 650 bacterial uropathogens isolates were collected from the laboratory units of the three mission hospitals and among them 529 Gram negative bacterial uropathogens were identified and re-confirmed following standard microbiological methods. Overall prevalence of uropathogens in these mission hospitals were 164 (80%), 222 (86%) and 143 (77%) from Hospital A, B and C respectively. E. coli with 58 (35%), 76 (34%) and 50 (35%) prevalence in hospital A, B and C respectively was the most prevalent and frequently isolated uropathogens. Imipenem and meropenem are the two most potent antibiotics against uropathogens in these Mission hospitals. In contrast, the isolated uropathogens developed 100% resistance to tigecycline, ertapenem, aztreonam and ampicillin/sulbactam.

Conclusion: Gram negative uropathogens are predominantly the most cause of UTIs and determination of antimicrobial susceptibility profiles of bacterial uropathogens has become crucial in the treatment of UTIs.


Bacterial; UTI; Prevalence; Antimicrobial Susceptibility.

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Anejo-Okopi AJ, Okwor, AEJ, Eze MI, Onaji AI, Ali M, Adekwu A, Ejiji IS. Prevalence and antibiotic resistance pattern of urinary tract bacterial infections among symptomatic patients attending university of Maiduguri teaching hospital, North East Nigeria. Euro J Adv Res Biol Life Sci2015;3(3):31-41.

Wubalem DS, Alemayehu DG. Prevalence and antibiotic susceptibility of uropathogens from cases of urinary tract infections (UTI) in Shashemene referral hospital, Ethiopia. BMC infect dis 2018;18(30):1-9.

Suwangool P. Current management of urinary tract infections. Bangk Med J2012;3:101-106.

Folliero V, Pina C, Maria TDR, Annalisa C, Marilena G, Maria RI., Cameron H, Gianluigi F, Massimiliano G. Prevalence and antimicrobial susceptibility patterns of bacterial pathogens in urinary tract infections in university hospital of Campania “Luigi Vanvitelli”between 2017 and 2018. Antibiotics 2020;9(215):1-9.

Iacovelli V, Gaziev G, Topazio L, Bove P, Vespasiani G, Agro EF. Nosocomial urinary tract infections: A review. Urol J2014;81:222–227.

Goel S, Mukherjee SB. Urinary tract infection, a tale of 50 years. Indian Pediatr2016;53: 57–58.

Ranganathan V. Urinary tract infection: an overview of the infection and the associated risk factors. J Microbiol Exp 2014;1(2):1-13.

Kolawole AS, Kolawole OM, Kandaki-Olukemi YT, Babatunde SK, Durowade KA, Kolawole CF. Prevalence of urinary tract infections (UTI) among patients attending Dalhatu Araf Specialist Hospital, Lafia, Nasarawa State, Nigeria. Int J Med Sci2009;1(5):163-167.

Iroha IR, Ukwuani EO, Moses IB, Ajah MI, Iroha CS, Ajah LO. Prevalence and characterization of multi-drug Resistant urothagens from children with urinary tract infections in children emergency unit of Federal teaching hospital, Abakaliki (FETHA), Nigeria. Int J Med Health Sci 2016;5(4):1-7.

Amdekar S, Singh V, Singh DD. Probiotic therapy: immunomodulating approach toward urinary tract infection. Curr Microbiol 2011;63(5):484–90.

Kent KH, Edward JB, Scholes D. Risk factors for urinary tract infections in postmenopausal women. Arch Intern Med 2014;164(9):989-993.doi:10.1001/archinte.164.9.989

Wilson ML, Gaido L. Laboratory diagnosis of urinary tract infections in adult patients. Clin Infect Dis 2004;38(8):1150-1158.

Ekwealor PA, Malachy CU, Ifeanyi E, George A, Belinda CU, Ugochukwu O, Catherine S, Charles E. Antimicrobial evaluation of bacterial isolates from urine specimen of patients with complaints of urinary tract infections in Awka, Nigeria. Int J Microbiol 2016;1-6.

Getenet B, Wondewosen T. Bacterial uropathogens in urinary tract infection and antibiotic susceptibility pattern in Jimma University Specialised Hospital, Southwest Ethiopia. Ethop J Health Sci 2011;21(2):141-6.

Abubakar EM (2009) Antimicrobial susceptibility pattern of pathogenic bacteria causing urinary tract infections at the specialist hospital, Yola Adamawa state, Nigeria. J Clin Med Res 2011;1(1):1-8.

Maduakor U, Udoh I, Ugwu L, Azubuike N, Onyemelukwe A, Onyebueke E, Onwukwe O, Ogu C. Uropathogens and antimicrobial susceptibility pattern in adult patients attending a tertiary hospital in Enugu, Nigeria. Inter J Infect Dis 2019;17(1):1-6.

Nwanze PI, Solomon O, Dimkpa U, Okwu M, Babatunde B, Anake T. Urinary tract infection in Okada village: Prevalence and antimicrobial susceptibility pattern. Sci Res Essays 2007;2:112-116.

Fariba A, Amirmorteza EN, Iman VS. Review Overview of Klebsiella Pneumoniae as a Nosocomial Pathogen and ESBL Producing Strains in Iran. Am J Infect Dis 2019:15(1):29-36.

Moges F, Mengistu G, Genetu A. Multiple drug resistance in urinary pathogens at Gondar College of Medical Sciences Hospital, Ethiopia. East Afr Med J 2002;79(8):415-419.

Egwu IH, Iroha IR, Elom PC, Agwu MM, and Ejikeugwu PC. Acinetobacter baumannii prevalence in Federal Teaching Hospital, Abakaliki, Nigeria. J Pharm Biol 2015;5(1):39-43.

Tatsuya T, Tomomi H, Shin W, Hiroki U, Mari TK, Kuwahara-Arai SM., Khin NZ, Teruo K, Htay HT. Molecular characterization of multidrug-resistant Pseudomonas aeruginosa isolates in hospitals in Myanmar. Antimicrob Agents Chemother 2019;63(5):1-6.

Cheesbrough M. District laboratory practice in tropical countries. part 2, Cambridge University Press, Cambridge, UK, 2004.

Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fifth Informational Supplement. CLSI document M100-S25 (ISBN 1-56238-989-0 [Print]; ISBN 1-56238-990-4 [Electronic]). Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087 USA, 2015.

Uwaezuoke JC, Ogbulie JN. Antibiotic sensitivity pattern of urinary tract pathogens in Port-Harcourt, Nigeria. J App Sci Environ Manage 2006;10(3):103-107.

Prakash D, Saxena RS. Distribution and antimicrobial susceptibility pattern of bacterial pathogens causing urinary tract infection in Urban Community of Meerut City, India. ISRN Microbiol 2013;1-13.

Gupta K, Scholes D, Stamm WE. Increasing prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in women. JAMA 1999;281(8):736-738.

Alo MN, Saidu AY, Ugah UI, Alhassan M. (2015). Prevalence and antibiogram of bacterial isolates causing urinary tract infections at Federal Teaching Hospital Abakaliki 1 (FETHA 1). Br Microbiol Res J 2015;8(2):403-417.

Okonko IO, Ijandipe LA, Ilusanya OA. Incidence of urinary tract infection (UTI) among pregnant women in Ibadan, South-Western Nigeria. Afr J Biotechnol 2009;8(23):6649-6657.

Iroha IR, Odeh E, Nwakaeze E, Agumah N, Iroha C, Ejikeugwu C. Antibiogram of uropathogenic Escherichia coli isolates from urine samples of pregnant women visiting St. Vincent hospital, Ndubia for ante- natal care. J Mol Bio Biotechnol 2017;2(3-6):1-4.

Ochada NS, Nasiru IA, Thairu Y, Okanlowan MB, Abdulakeem YO. Antimicrobial susceptibility pattern of urinary pathogens isolated from two tertiary hospitals in southwestern Nigeria. Afr J Clin Exper Microbiol 2015;16(1):12-22.

Okafor J, Nweze E. (2020). Antibiotic susceptibility of Echerichia coli isolated in cases of urinary tract infection in Nsukka, Nigeria. J Pre-clin Clin Res 2020;14(1):1-7.



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